The inherent limitations of animal models in fully capturing the heterogeneity and complexity of AD in human necessitate carefully designed clinical trials with well-defined patient populations and outcome measures
doi: 10.1126/science.285.5432.1393
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Overall, initial liver injury and intestinal barrier disruption cause fungal dysregulation, and the dysregulated fungal community (especially excessive proliferation of harmful strains) feeds back and accelerates CLDs progression through mechanisms such as metabolites, receptor pathways, and immunomodulation via the gut-liver axis 5,43
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10.1002/fsn3.3848 DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request